NOTCH3 and acute lymphoblastic leukemia: To analyze the putative role of Pin1 isomerase on both Notch1 and Notch3 protein expression and function in T-ALL context, Pin1 expression was silenced in different human T-ALL cell lines (Molt3, SilAll, P12-Ichikawa and Jurkat), all constitutively expressing activated Notch1-IC (N1Val1744) and Notch3-IC (N3IC) as shown in Figures 1b and c, respectively.