PIN1 and neoplasm: Consistently, while the non-lymphoid organs (liver and lung) of N3IC-tg mice showed a massive and diffuse tumor cell infiltration (Figure 4d, middle panels), already evident at 10 weeks of age, the N3IC-tg/Pin1−/− double mutant mice only display a little lymphoid cell infiltration around the vessels, restricted to the liver at late age (Figure 4d, right panels).