Altered degradation process and/or acetylation/deacetylation balance have been shown to have an important role in the control of Notch3 protein stability,12, 13 thus contributing to the sustained Notch3 overexpression and Notch3-dependent leukemia development in Notch3 transgenic mice.7 These observations suggest that Notch3 expression can be modified by more than one type of post-translational modification (PTM) event.14 Here, NOTCH3 is linked to leukemia.