NOTCH3 and neoplasm: To better address the role of Pin1–Notch3 axis in sustaining lymphoma cell migration/invasion and tumor progression, we analyzed the lymphoma development by evaluating the total cell yield and immunophenotype of SPL, lymph nodes and blood of double mutant N3IC-tg/Pin1−/− mice with respect to N3IC-tg littermates (Figure 4a).