CNR1 and neoplasm: Cannabinoid-mediated tumor killing was shown to involve mostly CB1 signaling: one path converging on an increase of ceramides that leads to the endoplasmic reticulum and oxidative stress [1], other pathways converging on Akt, Erk or MAP kinase inhibition [59,60], AMPK-mediated autophagy [61], cell cycle inhibition [62], or still unknown receptors and signaling pathways [63].