BCL2 and B-cell chronic lymphocytic leukemia: For example, a cancer dependent on Bcl-2 for survival, such as chronic lymphocytic leukemia (CLL), has an abundance of Bcl-2 that actively sequesters the BH3 protein, Bim, making the cancer cell “primed to die” in the event that other cellular stressors activate additional BH3 proteins to overcome the Bcl-2 binding capacity within the cell [3].