Functional characterization of Bcl-2 dependence patterns by co-immunoprecipitation (co-IP) confirmed that ABT-737 sensitive NB cell lines depend on Bcl-2 and not on Bcl-XL to sequester Bim for survival, making a large subset of NBs prime candidates for select Bcl-2 antagonism [19]. This evidence concerns the gene BCL2 and neuroblastoma.