The intravacuolar bacteria Chlamydia trachomatis and Salmonella typhimurium are likewise targeted by IFNγ‐driven host responses in the acute stages of infection, resulting in C. trachomatis reticulate bodies forming an aberrant non‐dividing form, and in S. typhimurium clearance (Kazar et al., 1971; Pie et al., 1997). The gene discussed is IFNG; the disease is infection.