The lifetime risk by age 70 of any LS-associated cancer has been found to range between 57 % [47] and close to 80 % [48] for MSH2 and 59 % [47] and ~65 % [48] for MLH1. For MSH6, lifetime risks of 25 % for males and females combined [47] and 24 % (males) and 40 % (females) [49] have been reported. This evidence concerns the gene MSH2 and cancer.