EGF and neoplasm: The non-angiogenic tumours are distinguished from the angiogenic tumours by having higher levels of proteins related to ephrin pathways, response to hypoxia, HIF1 regulation by oxygen, and transcription of HIF-controlled genes but lower levels of proteins involved in stromal cell–cell signaling and adhesion, integrins, and Delta-Notch- and EGF-related signaling.