In that study, the variant CT and TT genotypes at the polymorphic site C-1306T of TIMP-2 (rs243865) were associated with a reduced risk of breast cancer (OR = 0.490, 95% CI = 0.033-0.730), compared with the wild-type CC genotype, among 210 breast cancer patients and 290 healthy Tunisian women [7]. This evidence concerns the gene TIMP2 and breast cancer.