TP53 and multiple sclerosis: For instance, intron variants of the p53 gene were associated with ovarian cancer risk [77], intronic SNP rs8048002 in the MHC class II transactivation gene (MHC2TA) was associated with increased risk of inflammatory disease [78], and intronic SNP rs9282860 in serine-threonine kinase 11 is a genetic risk factor in women with multiple sclerosis [79].