Puglisi et al. [18] found a significant association between PN cytoplasmic epithelial expression and tumour size, PgR status, VEGF-A and VEGFR-1, and a significant association of nuclear PN expression and tumour size, ER and PgR status, VEGF-A, VEGFR-1 and VEGFR-2. This evidence concerns the gene KDR and neoplasm.