CRB1 and Leber congenital amaurosis: This same mutation was mentioned in the literature by Francesca Simonelli et al. [8] who thoroughly studied 95 patients with LCA, and found CRB1 mutations in 7.4 % of them, with the same p.I852T mutation (of our patients) in two patients of Italian ancestry, who were 40 and 45 years old and had severe loss of vision: perception of light in the first and hand movement in the second.