CRB1 gene mutation is a very well known risk factor for the development of coat’s like vasculopathy in RP patients, and our case presents the co-existence of the coat’s like reaction and LCA in a patient with CRB1 mutation, it is not obvious whether this mutation is responsible for the coat’s reaction as it was also described in other patients without causing the coat’s exudate. This evidence concerns the gene CRB1 and retinitis pigmentosa 1.