Levels of TFE3 (P < 0.01), HIF-1α (P < 0.01), PAI-1 (P < 0.01), and EGFR (P<0.01) during immunostaining exhibit light stains in the nuclear area or cytoplasm of oral mucosa but are significantly increased in HNSCC cores (Fig. 1A and S2). The gene discussed is TFE3; the disease is head and neck squamous cell carcinoma.