TGFB1 and neoplasm: Hypoxia inducible factor (HIF) plays a key role in tumor, and it is correlated with short disease-free survival by upregulating hypoxia-related factors, such as transforming growth factor-β (TGF-β) and plasminogen activator inhibitor type-1 (PAI-1), which play an important role in antiapoptotic and angiogenic factors and cancer stem cell initiation [5].