On the other hand, one study found that DARPP-32 reversed the multidrug resistance (MDR) of Adriamycin (ADR)-resistant gastric adenocarcinoma cells (SGC7901/ADR), as these cells were significantly sensitized to vincristine, ADR, 5-fluorouacil, and cisplatin in response to DARPP-32 up-regulation [52]. Here, PPP1R1B is linked to gastric adenocarcinoma.