TNM (P<0.0001), tumor size (P=0.001), lymph nodes metastasis (P<0.0001), CA19-9 (P=0.005), grade of differentiation (P<0.0001), HIF1A SNPs (P<0.0001), or HIF-1α expression (P<0.0001) all showed significant association with OS of patients with PDAC but age has no impact of PDAC prognosis. Here, HIF1A is linked to neoplasm.