It was reported that TRIM29 expression was correlated with poor histological grade, large tumor size, great extent of tumor invasion and lymph node metastasis in gastric cancer [20], and was increasing during the progress from normal pancreatic ductal epithelium to infiltrating cancer, which suggests that up-regulation of TRIM29 promote the development of invasive pancreatic cancer [13]. This evidence concerns the gene TRIM29 and familial pancreatic carcinoma.