The initial T-helper (Th)1 immune response[interferon (IFN)-g, interleukin (IL)-2 and IgG2a] against infective larvae antigens isinhibited on the 60th day post-infection (dpi) by a predominant Th2 immune response, withthe production of IL-4, IL-5, and IL-10 that are induced by egg antigens and promote theIgE and IgG1 production (Finkelman et al. 1991,Pearce et al. 1991, Moore et al. 2001). The gene discussed is IL10; the disease is infection.