To summarize, a strong correlation between IL-27 plasma levels and Dsg-specific IgG auto-ab titers, as well as elevated plasma levels of IL-21 along with increased frequencies of cTfh and Th17 cells suggest a potential implication of IL-27 and IL-21-producing T cells in the pathogenesis of pemphigus. The gene discussed is DSG1; the disease is pemphigus.