DSG3 and acquired polycythemia vera: Based on the strong prevalence of distinct human leukocyte antigen (HLA) class II alleles in PV, our group recently showed in an HLA-DRB1*04:02–transgenic mouse model of PV that HLA-DRB1*04:02-restricted T cell recognition of human Dsg3 is critical for the induction of pathogenic IgG abs that were capable of inducing intraepidermal loss of adhesion [10].