Multiple injury stimuli, such as transforming growth factor β1 (TGF-β1), tumor necrosis factor alpha (TNF-α), platelet derived growth factor (PDGF), angiotensin II (ANG II), hyperglycemia, oxidized low-density lipoprotein (oxLDL), albumin, and lipopolysaccharide (LPS) were affected to increase intracellular ROS production through by the increase of activity or expression of NADPH oxidase [21–24]. This evidence concerns the gene TNF and Hyperglycemia.