More recently, a significant association between SNPs in the single immunoglobulin interleukin 1 (IL-1) receptor (SIGIRR, also known as Toll IL-1 receptor 8 [Toll/IL-1R-8, TIR8] region including adjacent SNPs in plakophilin 3 (PKP3) and transmembrane 16J (TMEM16J) were associated with susceptibility to TB in Vietnam [15]. This evidence concerns the gene PKP3 and tuberculosis.