In childhood B-ALL patients, the significant peaks identified by GISTIC included the deletions of SETD2/3p21.31; FYN, FOXO3a, GRIK2, EPHA7, BLIMP1/6q16.3; KMT2A(MLL)/11q23.3; ETV6/12p13.2 and E2A(TCF3)/19p13.3 loci, whereas in the adult B-ALL cohort, the significant peaks included the deletions of MUC4/3q29; EBF1/5q33.3; RB1/ 13q14.2 and CREBBP/16p13.3 loci. The gene discussed is RB1; the disease is precursor B-cell acute lymphoblastic leukemia.