In agreement with previous studies using array-CGH or SNP array methods [7, 10, 15, 27, 28, 30–33, 36–42], many small (<5 Mb) genetic lesions detected in children and adults with ALL harbored biological and clinically relevant ALL-related genes, such as lymphoid transcription factors (PAX5, IKZF1 and EBF1), transcriptional regulators and coactivators (ETV6 and ERG), tumor suppressors (CDKN2A/B, RB1 and TP53), as well as putative regulators of apoptosis (BTG1) (C-H Tables in S1 File). The gene discussed is RB1; the disease is acute lymphoblastic leukemia.