CREB1 and myocardial infarction: CREB is a substrate forvarious cellular kinases (including Akt) (6).Attenuation of the reduction of expression of phospho-CREB in myocardial tissue canreduce the size of the myocardial infarct (18).Increasing expression of Akt in myocardial tissue can also reduce the size of themyocardial infarct, and Akt-dependent activation is dependent upon phospho-CREB (19).