Fig 2A shows the Kaplan-Meier curves for CSS and reveals that low TUSC3 level is a factor predictive of poor prognosis in PC patients (p = 0.0416, log-rank test). Among the 117 patients, recurrence occurred in 69 of 79 (87.3%) patients with low TUSC3 protein level and in 24 of 38 (63.2%) patients with high TUSC3 protein expression level (p<0.0001). Fig 2B shows the Kaplan-Meier curves for RFS and reveals that low TUSC3 level is a factor predictive of higher risk of recurrence in PC patients (p = 0.0043, log-rank test). Here, TUSC3 is linked to pachyonychia congenita.