KLK3 and posterior cortical atrophy: These results are not particularly surprising considering that PSA+ PCa cells all express high levels of nuclear AR [2, 3] and, in the absence of androgens (CDSS) and/or with the blockade of AR signaling (CDSS+bicalutamide and MDV3100), AR will be degraded leading to the death of AR+/PSA+ PCa cells and time-related enrichment of AR−/PSA− cells.