Significantly, although the PSA−/lo PCa cells are highly resistant to castration, prooxidants, and some chemotherapeutic drugs [2, 3], AEW541 exhibited inhibitory effects on both PSA+ as well as PSA−/lo LNCaP cells by causing increased apoptosis (Figure 6F–6G). The gene discussed is KLK3; the disease is posterior cortical atrophy.