MELK and small cell lung carcinoma: We also examined morphological changes induced by a MELK inhibitor OTS167 in SCLC cells and observed that MELK inhibitor-treated SCLC cells revealed dendrite-like neuronal protrusions (yellow arrows) as well as elongated intercellular bridges (white arrows), which were not observed in SCLC cells without the exposure to OTS167 (Figure 4A).