ANXA5 and cancer: To address the mechanism of the growth suppressive effects by OTS167, we further evaluated its effects on cancer cell death and found by flow cytometry analyses that treatment with OTS167 exhibited a greater proportion of early apoptotic cells (Annexin-V+/PI-) as well as necrotic (Annexin-V+/PI+) cells in both suspension and adherent SCLC cells (Figure 6A and 6B).