CEA was originally characterized as an adhesive molecule and a chemoattractant.34 Many preclinical and experimental studies disclosed the promoting adhesive function of tumor cells to the endothelium activated by CEA.35 Thus, serum CEA may partly contribute to the metastatic distribution into the whole-body and has a strong affinity to specific sites by its function as an adhesion molecule. The gene discussed is CEACAM5; the disease is neoplasm.