IFNG and infectious disease: High levels of IgG are associated with an elevated risk of death from all-cause mortality, but most importantly from infectious disease.46 In addition, some auto-antibodies such as anti-GM-CSF47 and anti-IFN-γ have been associated with CM in otherwise immunocompetent patients.48 Hence, in addition to total IgG, it may also be useful to follow auto-antibodies specific for inflammatory cytokines during infection.