It has also been reported that no or mild meningeal contrast enhancement is demonstrated in HIV-infected patients due to their immunodeficiency and immunogenic incompetence in recognizing polysaccharide capsule of cryptococcal organism.11,12,24 In our group of patients with lower CD4 T cell count, the lesions commonly involved the central part of brain, with no detected contrast enhancement that is related to the compromised response to the infection. Here, CD4 is linked to infection.