ACE and hydrops fetalis: Because ACE inhibitors have a modest effect on the remodeling of left ventricular (LV) to some extent, the European Society of Cardiology (ESC) Guidelines for HF recommend that ACE inhibitors be prescribed immediately after HF is diagnosed.4 Two randomized controlled trials have demonstrated that ACE inhibitors therapy decreased mortality.5,6 These findings are similar with the results from a meta-analysis including short-term (3 months), placebo-controlled randomized controlled trials.7