On the basis of our blood genomic pathways, we sought to evaluate the expression (qRT-PCR) of genes linked to granzyme signaling, cytotoxic T cell signaling and T cell inhibition, namely GZMA, GZMB, KLRD1, CD8A, CD8B, LAG3, PRF1 and KLRD1 (Fig 4) in a second independent cohort of ICU patients consisting of 12 HIV positive and 24 matched HIV negative patients with sepsis. The gene discussed is LAG3; the disease is Sepsis.