Additionally, even though we did not find evidence for reduced AVP and VIP immunoreactivity in the SCN of the BACHD animals at 3 months of age (Fig 3), VIP has been reported to be reduced in the SCN of the R6/2 model of HD late in disease progress [78] as well as in HD patients post-mortem [79]. The gene discussed is VIP; the disease is Huntington disease.