POU5F1 and cancer: Interestingly, the “Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency” canonical pathway was among the pathways, significantly upregulated upon LY75 knockdown in SKOV3 cells (see Supplemental Figure 6A), which supports literature data underlying the superior capability of cancer cells bearing the epithelial phenotype to maintain ES cells-like features that are essential for self-renewal, pluripotency, and enhanced invasiveness [50].