BRAF and cancer: In this subset, a mutation in BRAF V(600)E was identified in whole exome sequencing (WES) of a single typical case at disease presentation [8], and due to the known prominence of this mutation more broadly in cancer, led to its selection and verification by conventional PCR-based screens in a larger number of HCLc tumours to establish it as a signature genetic mutation in this disease subtype [8,9,10].