Significantly, mutant BRAF V(600)E has also been identified in HSCs from patients with Langerhans cell histiocytosis (LCH) [45], a condition characterised by pathological accumulation of CD207+dendritic cells to indicate that this lesion in HSCs can also drive clonal proliferation in the myeloid cell compartment. Here, CD207 is linked to Langerhans cell histiocytosis.