HLA-B and neoplasm: Taking advantage of gene expression data, we realized that this tumor had a marked under-expression of indispensable genes for the neoantigen presentation such as HLA-A, HLA-B, HLA-C, TAP1, and TAP2. Consequently, under the hypothesis that neoantigens only activate immune response if correctly presented by antigen presentation machinery, the levels of expression of these genes were analyzed in the complete sample of 98 tumors of the Colonomics study with expression data that included those 42 analyzed by NGS.