DNMT3B and endocrine gland neoplasm: To determine if inactivation of menin increased the other three DNA methyltransferases (DNMT2, DNMT3a, and DNMT3b), we measured mRNA expression levels in the endocrine tumors from MEN1 patient samples and Men1 KO mouse models, and demonstrated no significant increase in DNMT2, DNMT3a, and DNMT3b (Supplementary Figure 4).