Five Sox genes (Sox2, Sox3, Sox5, Sox9, and Sox11) showed significantly decreased mRNA expression (from 4 to 12 fold) in the endocrine tumor tissues of the pancreas and the parathyroids from Pdx1-Cre:Men1 floxed/floxed and Pth-Cre:Men1 floxed/floxed KO mice compared to normal endocrine tissues from the pancreas and parathyroids from control Pdx1-Cre and Pth-Cre mice, respectively (Figure 8A and 8B). Here, SOX5 is linked to endocrine gland neoplasm.