Given their higher mutational load and unique mutational signature, we hypothesized that BRCA1/2-mutated tumors may harbor more tumor-specific neoantigens, and, therefore, increased tumor-infiltrating lymphocytes (TILs) [7] as well as demonstrate increased expression of the immune checkpoint modulators, PD-1 and PD-L1. This evidence concerns the gene BRCA1 and neoplasm.