HAX-1 expression is a predictor of tumorigenesis, growth, progression, invasion, and metastasis of many human malignancies [13, 14], and is overexpressed in many tumors [13, 15, 16] such as esophageal squamous cell carcinoma [17, 18], colorectal cancer [19], oral squamous cell carcinoma, lung cancer, lymphoma, melanoma [20], leukemia, myeloma, breast cancer, and hepatoma [21]. The gene discussed is HAX1; the disease is esophageal squamous cell carcinoma.