CRP and periodontitis: For plasma CRP levels, their positive titers were detected from all participants and the magnitude was highest in patients with MS and severe periodontitis (2,290.9 (1,189.6, 3,445.0) ng/mL), lower in patients with MS but without severe periodontitis (1,897.0 (1,138.8, 3,649.2) ng/mL), lower still in healthy participants with severe periodontitis (929.1 (404.0, 1,463.0) ng/mL), and lowest in healthy participants without severe periodontitis (770.5 (269.9, 1,658.4) ng/mL) (Fig 1).