Individuals with high CRP levels, high BMI, severe periodontitis status and low levels of plasma IgG to A. actinomycetemcomitans had a significantly higher association with MS than those who had high levels of plasma IgG to A. actinomycetemcomitans, low CRP levels, low BMI and healthy periodontal status (Table 3). This evidence concerns the gene CRP and periodontitis.