Because there are many clinicopathological and molecular similarities between SSA/Ps and CIMP-high colorectal cancers, including proximal tumor location, BRAF mutation, and MLH1 methylation, SSA/Ps are hypothesized to be precursor lesions that develop into CIMP-high colorectal cancers [31, 42, 46, 50, 51]. This evidence concerns the gene MLH1 and colorectal cancer.