In order to validate CK2 as a potential driver or mediator of the TNF network, we directly inhibited the kinase activity by silencing CK2 expression, using siRNA, in two ovarian cancer cell lines, IGROV-1 and SKOV3ip1, with similar constitutive TNF, IL6 and VEGF secretion into cell culture supernatants. The gene discussed is TNF; the disease is ovarian carcinoma.