More intriguingly, the induced expression changes of these immune-modulatory receptors including NKG2D, LAG-3, and CTLA-4 on the CIK cells when engaged with the tumor cells like MGC803 cells, were largely consistent with the differences between gastric tumor tissues and matched adjacent normal samples observed at the mRNA levels in examined specimens (Figure 6D). This evidence concerns the gene LAG3 and gastric neoplasm.