Interestingly, quantitative real time PCR analysis conducted in the present study also demonstrated significantly higher SERCA2b/SERCA3 mRNA expression ratios in KG1a and U937 cells compared to PBMC (Supplementary Figure S9), suggesting that SERCA2b may have a role in the selective cytotoxicity of CUR+CA in AML cells. Here, ATP2A3 is linked to acute myeloid leukemia.