Overall, TP53 inactivation as a result of gene deletion and/or mutation occurred in 7% of MM, 37.5% of pPCL and 44.4% of sPCL patients; in particular, the two lesions were simultaneously present respectively in 0.8%, 16.7% and 22.2% of cases, causing biallelic gene inactivation. This evidence concerns the gene TP53 and Miyoshi myopathy.