Laboratory evaluation of CIRS reveals increases in C4a (complement component 4a), TGF- β1 (transforming growth factor beta-1), MMP9 (matrix metalloprotease 9), specific cytokines, and decreases in MSH (melanocyte-stimulating hormone), VEGF (vascular endothelial growth factor), and ADH (anti-diuretic hormone), as well as frequent hypercortisolemia, hypozincemia, and other abnormalities. The gene discussed is VEGFA; the disease is adrenal gland hyperfunction.