Indeed, the three different types of Alzheimer's disease that are distinguishable based on metabolic profiling fit well with the three known effects of amyloids such as Aβ: Aβ is produced in response to infection, and exhibits antimicrobial effects [10]; furthermore, Aβ is a component of the inflammatory response, with NFκB inducing proteases involved in its formation. Here, NFKB1 is linked to early-onset autosomal dominant Alzheimer disease.