However, his other symptoms and laboratory values supported both a diagnosis of CIRS and a diagnosis of type 3 AD: his headache, depression, irritability, markedly elevated TGF-β1, HLA haplotypes characteristic of biotoxin sensitivity (11-3-52B) and mold sensitivity (13-6-52B), positive nasopharyngeal culture for MARCoNS, autoantibodies, and the presence of Aspergillus and Penicillium in his home, are all compatible with a diagnosis of CIRS. Here, TGFB1 is linked to major depressive disorder.