This clarification may impact the research community as follows: 1) Since the S2R has been found to be functionally important in cancer and neuronal diseases (Cassano et al., 2006, Crawford and Bowen, 2002, Kashiwagi et al., 2009, Vilner and Bowen, 2000, Vilner et al., 1995, Wheeler et al., 2000), the findings reported herein pose a timely reminder that the true, high-affinity DTG binding S2R has yet to be cloned. This evidence concerns the gene TMEM97 and cancer.