Pharmacological and chemical biology studies have revealed that the S2R is highly expressed in tumors and S2R ligands have shown anti-cancer effects (Crawford and Bowen, 2002, Hornick et al., 2010, Kashiwagi et al., 2009, Vilner and Bowen, 2000, Vilner et al., 1995, Wheeler et al., 2000). The gene discussed is TMEM97; the disease is cancer.