Various studiesconducted on obese metabolic syndrome patients versus obese non-metabolic syndrome patients reported higher levels and positive correlation of ferrit in with BMI between the groups, arguing against the presence of iron overload and advocating some level of inflammation responsible for high levels of ferritin (Table-II and Fig.1).28,29 In a recent study conducted by our group, we found elevated levels of serum ferritin, insulin, HOMA-IR and hs-CRP with low serum iron levels in Type II diabetics. Here, INS is linked to Tangier disease.