SH2B3 and immune system disorder: SH2B3 thus seems more likely relevant to vitiligo susceptibility than ATXN2. SH2B3 is also involved in the development regulation of both B and T cells, and associated with some immune diseases, including T1D (Devalliere and Charreau, 2011), RA (Coenen et al., 2009), and lupus (Li et al., 2010).