SH2B3 thus seems more likely relevant to vitiligo susceptibility than ATXN2. SH2B3 is also involved in the development regulation of both B and T cells, and associated with some immune diseases, including T1D (Devalliere and Charreau, 2011), RA (Coenen et al., 2009), and lupus (Li et al., 2010). Here, SH2B3 is linked to systemic lupus erythematosus.