FFAR2 and gout: Interestingly, Macia et al. (44) suggested that GPR43 was required for the induction of IL-18 expression to reduce colitis severity presumably via increased inflammasome activation in epithelial cells while Vieira et al. (45) suggested that GPR43 exacerbated joint inflammation in a mouse model of gout by inducing inflammasome formation in macrophages.