Activated T cells upregulate the surface expression of key nutrients receptors, such as the amino acid and glucose transporters, triggering the hypoxia-inducible factor-α (HIF1-α), c-Myc, and the PI3K/Akt/mTOR (the mammalian target of rapamycin) (17, 18), which play a pivotal role in energetic adaptations of both cancer and immune cells (19). Here, HIF1A is linked to cancer.