In a review of double pituitary adenomas, including tumors with pathological report albeit incomplete endocrine evaluation, Iacovazzo et al. identified coexistent ACTH- and PRL-secreting synchronous tumors in 33% of cases, closely followed by combined non-functional and GH-secreting pituitary adenomas (24%), GH- and PRL-secreting tumors (10%), and non-functional adenomas combined with either ACTH-secreting (7%) or PRL-secreting tumors (7%). Here, POMC is linked to adenoma.