Endostatin has also been fused to protein sequences targeting it to tumors and/or tumor vasculature such as humanized antibodies against tyrosine kinase-type receptor HER2 (Shin et al., 2011) or against tumor-associated glycoprotein 72 highly expressed in human tumor tissues (Lee et al., 2015), the RGD integrin-binding sequence (Jing et al., 2011), and a liver-targeting peptide (circumsporozoite protein CSP I-plus (Ma et al., 2014; Bao et al., 2015). Here, ERBB2 is linked to neoplasm.