The presence of syndecan-1 is associated with favorable outcomes in both lung cancer and mesothelioma (Kumar-Singh et al., 1998; Anttonen et al., 2001), and the loss of syndecan-1 is a feature of hepatocellular carcinoma with high metastatic potential (Matsumoto et al., 1997). The gene discussed is SDC1; the disease is hepatocellular carcinoma.